Engineering synthetic vaccines using cues from natural immunity.

نویسندگان

  • Darrell J Irvine
  • Melody A Swartz
  • Gregory L Szeto
چکیده

Vaccines aim to protect against or treat diseases through manipulation of the immune response, promoting either immunity or tolerance. In the former case, vaccines generate antibodies and T cells poised to protect against future pathogen encounter or attack diseased cells such as tumours; in the latter case, which is far less developed, vaccines block pathogenic autoreactive T cells and autoantibodies that target self tissue. Enormous challenges remain, however, as a consequence of our incomplete understanding of human immunity. A rapidly growing field of research is the design of vaccines based on synthetic materials to target organs, tissues, cells or intracellular compartments; to co-deliver immunomodulatory signals that control the quality of the immune response; or to act directly as immune regulators. There exists great potential for well-defined materials to further our understanding of immunity. Here we describe recent advances in the design of synthetic materials to direct immune responses, highlighting successes and challenges in prophylactic, therapeutic and tolerance-inducing vaccines.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Novel Approaches for the Design of Vaccines against Infectious and Autoimmune Diseases

The renaissance in vaccine research during the past decade led to several new approaches towards vaccine development. One is the evaluation of the potential of synthetic peptides corresponding to sequences of microbial proteins, comprising defined epitopes, to elicit antibodies with capacity to inactivate the respective pathogens and to protect against infection. Focusing on influenza, a novel ...

متن کامل

Elimination of Cd2+ and Mn2+ from Wastewaters Using Natural Clinoptilolite and Synthetic Zeolite P

This study deals with the uptake of Cd2+ and  Mn2+ ions from contaminated water using two Iranian natural clinoptilolite-rich tuffs from Meyaneh (Z-m), and Semnan (Z-s) regions , and a synthetic zeolite-P from Z-m sample (Z-P) under static (batch operation) and dynamic (column operation) conditions. To investigate the selectivity of the zeolites towar...

متن کامل

Cancer Immunology at the Crossroads: Engineering Engineering New Approaches to Cancer Vaccines

Recently, a number of promising approaches have been developed using synthetic chemistry, materials science, and bioengineering-based strategies to address challenges in the design of more effective cancer vaccines. At the stage of initial priming, potency can be improved by maximizing vaccine delivery to lymph nodes. Because lymphatic uptake from peripheral tissues is strongly size dependent, ...

متن کامل

Of natural bodies and antibodies: Parents' vaccine refusal and the dichotomies of natural and artificial.

Despite eliminating incidences of many diseases in the United States, parents are increasingly rejecting vaccines for their children. This article examines the reasons parents offer for doing so. It argues that parents construct a dichotomy between the natural and the artificial, in which vaccines come to be seen as unnecessary, ineffective, and potentially dangerous. Using qualitative data fro...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Nature materials

دوره 12 11  شماره 

صفحات  -

تاریخ انتشار 2013